InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DOCK2

Summary

InnateDB Protein

IDBP-57110.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DOCK2

Protein Name

dedicator of cytokinesis 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000256935

InnateDB Gene

IDBG-57108 (DOCK2)

Protein Structure

UniProt Annotation

Function

Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269PubMed:21613211}.

Subcellular Localization

Endomembrane system {ECO:0000269PubMed:12393632}; Peripheral membrane protein {ECO:0000269PubMed:12393632}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:12393632}. Note=Colocalizes with F-actin.

Disease Associations

Tissue Specificity

Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon. {ECO:0000269PubMed:10559471}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0020037	heme binding
GO:0030675	Rac GTPase activator activity
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0042608	T cell receptor binding

Biological Process

GO:0001766	membrane raft polarization
GO:0001768	establishment of T cell polarity
GO:0001771	immunological synapse formation
GO:0002277	myeloid dendritic cell activation involved in immune response
GO:0006935	chemotaxis
GO:0007010	cytoskeleton organization
GO:0007264	small GTPase mediated signal transduction
GO:0016032	viral process
GO:0030036	actin cytoskeleton organization
GO:0032855	positive regulation of Rac GTPase activity
GO:0042098	T cell proliferation
GO:0042110	T cell activation
GO:0044351	macropinocytosis
GO:0045059	positive thymic T cell selection
GO:0045060	negative thymic T cell selection
GO:0046631	alpha-beta T cell activation
GO:0046633	alpha-beta T cell proliferation
GO:0050690	regulation of defense response to virus by virus
GO:0050766	positive regulation of phagocytosis

Cellular Component

GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR009056 Cytochrome c-like domain
IPR009078 Ferritin-like superfamily
IPR010703 Dedicator of cytokinesis C-terminal
IPR011511 Variant SH3 domain
IPR016024 Armadillo-type fold

PFAM

PF00018
PF14604
PF13442
PF06920
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00326

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt