InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LCP2

Summary

InnateDB Protein

IDBP-57218.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LCP2

Protein Name

lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)

Synonyms

SLP-76; SLP76;

Species

Homo sapiens

Ensembl Protein

ENSP00000046794

InnateDB Gene

IDBG-57216 (LCP2)

Protein Structure

UniProt Annotation

Function

Involved in T-cell antigen receptor mediated signaling.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	68 [view]
Protein-Protein	67 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0045576	mast cell activation
GO:0050663	cytokine secretion
GO:0050852	T cell receptor signaling pathway