InnateDB Protein
|
IDBP-57457.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
NPM1
|
Protein Name
|
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
|
Synonyms
|
B23; NPM;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000341168
|
InnateDB Gene
|
IDBG-57453 (NPM1)
|
Protein Structure
|
|
Function |
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double- stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. {ECO:0000269PubMed:12882984, ECO:0000269PubMed:16107701, ECO:0000269PubMed:17015463, ECO:0000269PubMed:18809582, ECO:0000269PubMed:19188445, ECO:0000269PubMed:20352051, ECO:0000269PubMed:21084279, ECO:0000269PubMed:22002061}.
|
Subcellular Localization |
Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML. Can shuttle between cytoplasm and nucleus. Co- localizes with the methylated form of RPS10 in the granular component (GC) region of the nucleolus. Colocalized with nucleolin and APEX1 in nucleoli. Isoform 1 of NEK2 is required for its localization to the centrosome during mitosis.
|
Disease Associations |
Note=A chromosomal aberration involving NPM1 is found in a form of non-Hodgkin lymphoma. Translocation t(2;5)(p23;q35) with ALK. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively activated.Note=A chromosomal aberration involving NPM1 is found in a form of acute promyelocytic leukemia. Translocation t(5;17)(q32;q11) with RARA.Note=A chromosomal aberration involving NPM1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with MLF1.Note=Defects in NPM1 are associated with acute myelogenous leukemia (AML). Mutations in exon 12 affecting the C- terminus of the protein are associated with an aberrant cytoplasmic location.
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 440 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated |
Total |
441
[view]
|
Protein-Protein |
438
[view]
|
Protein-DNA |
3
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
38 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR024057
Nucleoplasmin core domain
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P06748
|
PhosphoSite |
PhosphoSite-P06748
|
TrEMBL |
E5RI98
|
UniProt Splice Variant |
|
Entrez Gene |
4869
|
UniGene |
Hs.735618
|
RefSeq |
NP_954654
|
HUGO |
HGNC:7910
|
OMIM |
164040
|
CCDS |
CCDS4377
|
HPRD |
01246
|
IMGT |
|
EMBL |
AB042278
AB451236
AB451361
AC091980
AC093246
AK290652
AY347529
AY740634
AY740635
AY740636
AY740637
AY740638
AY740639
AY740640
BC002398
BC008495
BC009623
BC012566
BC014349
BC016716
BC016768
BC016824
BC021668
BC021983
BC050628
BC107754
BT007011
CH471062
D45915
DQ303464
J02590
M23613
M26697
M28699
M31004
U04946
U41742
U41743
U89309
U89310
U89311
U89313
U89314
U89317
U89319
U89321
X16934
|
GenPept |
AAA36380
AAA36385
AAA36473
AAA36474
AAA58386
AAA58698
AAB00112
AAB00113
AAB94739
AAH02398
AAH08495
AAH09623
AAH12566
AAH14349
AAH16716
AAH16768
AAH16824
AAH21668
AAH21983
AAH50628
AAI07755
AAP35657
AAQ24860
AAW67752
AAW67753
AAW67754
AAW67755
AAW67756
AAW67757
AAW67758
ABC40399
BAA08343
BAB40600
BAF83341
BAG70050
BAG70175
CAA34809
EAW61443
EAW61446
|
|
|