InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FGF18

Summary

InnateDB Protein

IDBP-57569.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGF18

Protein Name

fibroblast growth factor 18

Synonyms

FGF-18; ZFGF5;

Species

Homo sapiens

Ensembl Protein

ENSP00000274625

InnateDB Gene

IDBG-57567 (FGF18)

Protein Structure

UniProt Annotation

Function

Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation. {ECO:0000269PubMed:16597617}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005105	type 1 fibroblast growth factor receptor binding
GO:0005111	type 2 fibroblast growth factor receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0001503	ossification
GO:0001525	angiogenesis
GO:0001957	intramembranous ossification
GO:0001958	endochondral ossification
GO:0002063	chondrocyte development
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007399	nervous system development
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009653	anatomical structure morphogenesis
GO:0030324	lung development
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032332	positive regulation of chondrocyte differentiation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade