InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KAT5

Summary

InnateDB Protein

IDBP-57610.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KAT5

Protein Name

K(lysine) acetyltransferase 5

Synonyms

cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP; TIP60; ZC2HC5;

Species

Homo sapiens

Ensembl Protein

ENSP00000344955

InnateDB Gene

IDBG-57604 (KAT5)

Protein Structure

UniProt Annotation

Function

Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. {ECO:0000269PubMed:12776177, ECO:0000269PubMed:14966270, ECO:0000269PubMed:15042092, ECO:0000269PubMed:15121871, ECO:0000269PubMed:15310756, ECO:0000269PubMed:16141325, ECO:0000269PubMed:16387653, ECO:0000269PubMed:17996965, ECO:0000269PubMed:19909775, ECO:0000269PubMed:24463511}.

Subcellular Localization

Nucleus. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 274 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	274 [view]
Protein-Protein	259 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	7 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0046872	metal ion binding
GO:0050681	androgen receptor binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006302	double-strand break repair
GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0010212	response to ionizing radiation
GO:0016032	viral process
GO:0016573	histone acetylation
GO:0030521	androgen receptor signaling pathway
GO:0032703	negative regulation of interleukin-2 production
GO:0040008	regulation of growth
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071392	cellular response to estradiol stimulus

Cellular Component

GO:0000812	Swr1 complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0032777	Piccolo NuA4 histone acetyltransferase complex
GO:0035267	NuA4 histone acetyltransferase complex
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000953 Chromo domain/shadow
IPR002717 MOZ/SAS-like protein
IPR016181 Acyl-CoA N-acyltransferase
IPR016197 Chromo domain-like
IPR025995 RNA binding activity-knot of a chromodomain

PFAM

PF01853
PF11717

PRINTS

PIRSF

SMART

SM00298

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92993