Version 5.4
Homo sapiens Protein: AUP1
Summary
InnateDB Protein IDBP-57686.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AUP1
Protein Name ancient ubiquitous protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000366748
InnateDB Gene IDBG-57682 (AUP1)
Protein Structure
UniProt Annotation
Function May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. {ECO:0000269PubMed:18711132}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:12042322, ECO:0000269PubMed:18711132}; Single-pass type III membrane protein {ECO:0000269PubMed:12042322, ECO:0000269PubMed:18711132}; Cytoplasmic side {ECO:0000269PubMed:12042322, ECO:0000269PubMed:18711132}.
Disease Associations
Tissue Specificity Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain. {ECO:0000269PubMed:12042322}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
Experimentally validated
Total 46 [view]
Protein-Protein 43 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003892 Ubiquitin system component Cue
PFAM PF02845
PRINTS
PIRSF
SMART SM00546
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y679
PhosphoSite PhosphoSite-Q9Y679
TrEMBL
UniProt Splice Variant
Entrez Gene 550
UniGene
RefSeq NP_853553
HUGO HGNC:891
OMIM 602434
CCDS CCDS42702
HPRD 03892
IMGT
EMBL AF100746 AF100753 AF100754 AF165515 AK023983 BC001658 BC033646 CH471053
GenPept AAD43010 AAD43017 AAD43018 AAF86645 AAH01658 AAH33646 BAB14753 EAW99623

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca