InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VASP

Summary

InnateDB Protein

IDBP-57718.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VASP

Protein Name

vasodilator-stimulated phosphoprotein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000245932

InnateDB Gene

IDBG-57716 (VASP)

Protein Structure

UniProt Annotation

Function

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin- bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. {ECO:0000269PubMed:10087267, ECO:0000269PubMed:10438535, ECO:0000269PubMed:15939738, ECO:0000269PubMed:17082196, ECO:0000269PubMed:18559661}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell junction, tight junction {ECO:0000250}. Cell projection, lamellipodium membrane. Cell projection, filopodium membrane. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments throughout the peripheral cytoplasm under basal conditions. In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes).

Disease Associations

Tissue Specificity

Highly expressed in platelets. {ECO:0000269PubMed:7828592}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	78 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005522	profilin binding
GO:0017124	SH3 domain binding

Biological Process

GO:0001843	neural tube closure
GO:0007411	axon guidance
GO:0008154	actin polymerization or depolymerization
GO:0030036	actin cytoskeleton organization
GO:0030838	positive regulation of actin filament polymerization
GO:0034329	cell junction assembly
GO:0045087	innate immune response (InnateDB)
GO:0050852	T cell receptor signaling pathway
GO:0051289	protein homotetramerization

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0005925	focal adhesion
GO:0015629	actin cytoskeleton
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0031258	lamellipodium membrane
GO:0031527	filopodium membrane
GO:0070062	extracellular vesicular exosome