InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP2R3A

Summary

InnateDB Protein

IDBP-57745.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP2R3A

Protein Name

protein phosphatase 2, regulatory subunit B'', alpha

Synonyms

PPP2R3; PR130; PR72;

Species

Homo sapiens

Ensembl Protein

ENSP00000264977

InnateDB Gene

IDBG-57743 (PPP2R3A)

Protein Structure

UniProt Annotation

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in heart, brain, placenta, lung, muscle and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008601	protein phosphatase type 2A regulator activity

Biological Process

GO:0001754	eye photoreceptor cell differentiation
GO:0006470	protein dephosphorylation
GO:0007525	somatic muscle development
GO:0045732	positive regulation of protein catabolic process
GO:0050790	regulation of catalytic activity
GO:0061053	somite development
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090244	Wnt signaling pathway involved in somitogenesis
GO:0090249	regulation of cell motility involved in somitogenic axis elongation
GO:0090263	positive regulation of canonical Wnt signaling pathway