InnateDB Protein
|
IDBP-57747.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
PPP2R3A
|
Protein Name
|
protein phosphatase 2, regulatory subunit B'', alpha
|
Synonyms
|
PPP2R3; PR130; PR72;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000334748
|
InnateDB Gene
|
IDBG-57743 (PPP2R3A)
|
Protein Structure
|
|
Function |
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
|
Subcellular Localization |
|
Disease Associations |
|
Tissue Specificity |
Expressed in heart, brain, placenta, lung, muscle and kidney.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
|
Protein-Protein |
11
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
3 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0001754
|
eye photoreceptor cell differentiation
|
GO:0006470
|
protein dephosphorylation
|
GO:0007525
|
somatic muscle development
|
GO:0045732
|
positive regulation of protein catabolic process
|
GO:0050790
|
regulation of catalytic activity
|
GO:0061053
|
somite development
|
GO:0090090
|
negative regulation of canonical Wnt signaling pathway
|
GO:0090244
|
Wnt signaling pathway involved in somitogenesis
|
GO:0090249
|
regulation of cell motility involved in somitogenic axis elongation
|
GO:0090263
|
positive regulation of canonical Wnt signaling pathway
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR002048
EF-hand domain
|
PFAM |
PF00036
PF13202
PF13405
|
PRINTS |
|
PIRSF |
|
SMART |
SM00054
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q06190
|
PhosphoSite |
PhosphoSite-Q06190
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
5523
|
UniGene |
Hs.705580
|
RefSeq |
NP_871626
|
HUGO |
HGNC:9307
|
OMIM |
604944
|
CCDS |
CCDS3088
|
HPRD |
09225
|
IMGT |
|
EMBL |
AC072039
AC092991
AK293012
AK298059
AK316258
AL389975
CH471052
L07590
L12146
|
GenPept |
AAB02613
AAB02614
BAF85701
BAG60353
BAH14629
CAB97532
EAW79122
EAW79123
|
|
|