InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LOXL3

Summary

InnateDB Protein

IDBP-57848.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LOXL3

Protein Name

lysyl oxidase-like 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000264094

InnateDB Gene

IDBG-57846 (LOXL3)

Protein Structure

UniProt Annotation

Function

Both isoforms function as amine oxidases toward elastin and different types of collagens. Isoform 1 shows the highest activity toward collagen type VIII, while Isoform 2 presents the highest activity toward collagen type IV. {ECO:0000269PubMed:17018530}.

Subcellular Localization

Isoform 1: Secreted, extracellular space {ECO:0000305}.Isoform 2: Cytoplasm {ECO:0000269PubMed:17018530}. Secreted, extracellular space {ECO:0000269PubMed:17018530}.

Disease Associations

Tissue Specificity

Isoform 1 ia predominantly detected in the heart, placenta, lung, and small intestine, while isoform 2 is more highly detected in the kidney, pancreas, spleen, and thymus, and is absent in lung. {ECO:0000269PubMed:17018530}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004720	protein-lysine 6-oxidase activity
GO:0005044	scavenger receptor activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

Biological Process

GO:0001837	epithelial to mesenchymal transition
GO:0006898	receptor-mediated endocytosis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process