InnateDB Protein
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IDBP-58243.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CST6
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Protein Name
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cystatin E/M
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000311313
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InnateDB Gene
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IDBG-58241 (CST6)
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Protein Structure
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Function |
Shows moderate inhibition of cathepsin B but is not active against cathepsin C.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Restricted to the stratum granulosum of normal skin, the stratum granulosum/spinosum of psoriatic skin, and the secretory coils of eccrine sweat glands. Low expression levels are found in the nasal cavity. {ECO:0000269PubMed:11348457}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004869
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cysteine-type endopeptidase inhibitor activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000010
Proteinase inhibitor I25, cystatin
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PFAM |
PF00031
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PRINTS |
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PIRSF |
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SMART |
SM00043
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TIGRFAMs |
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Modification |
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SwissProt |
Q15828
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PhosphoSite |
PhosphoSite-Q15828
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1474
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UniGene |
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RefSeq |
NP_001314
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HUGO |
HGNC:2478
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OMIM |
601891
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CCDS |
CCDS8126
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HPRD |
03535
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IMGT |
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EMBL |
AY145051
BC031334
U62800
U81233
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GenPept |
AAB06566
AAB61305
AAH31334
AAN52757
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