Version 5.4
Homo sapiens Protein: ZDHHC15
Summary
InnateDB Protein IDBP-583263.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZDHHC15
Protein Name zinc finger, DHHC-type containing 15
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000445420
InnateDB Gene IDBG-77446 (ZDHHC15)
Protein Structure
UniProt Annotation
Function Palmitoyltransferase specific for GAP43 and DLG4/PSD95. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations Mental retardation, X-linked 91 (MRX91) [MIM:300577]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non- syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed in placenta, liver, lung, kidney, heart and brain. {ECO:0000269PubMed:15915161}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0008270 zinc ion binding
GO:0016409 palmitoyltransferase activity
GO:0019706 protein-cysteine S-palmitoyltransferase activity
Biological Process
GO:0007275 multicellular organismal development
GO:0018345 protein palmitoylation
Cellular Component
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001594 Zinc finger, DHHC-type, palmitoyltransferase
IPR016201 Plexin-like fold
PFAM PF01529
PRINTS
PIRSF
SMART SM00423
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96MV8
PhosphoSite PhosphoSite-Q96MV8
TrEMBL
UniProt Splice Variant
Entrez Gene 158866
UniGene Hs.253211
RefSeq NP_001139728
HUGO HGNC:20342
OMIM 300576
CCDS CCDS55454
HPRD 06758
IMGT
EMBL AC020717 AK056374 AK122885 AL137013 AL391055 AY358786 BC103980 BC103981 BC103982
GenPept AAI03981 AAI03982 AAI03983 AAQ89146 BAB71168 BAG53779 CAI40090

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca