InnateDB Protein
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IDBP-583401.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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USP44
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Protein Name
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ubiquitin specific peptidase 44
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000442629
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InnateDB Gene
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IDBG-51735 (USP44)
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Protein Structure
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Function |
Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination. {ECO:0000269PubMed:17443180, ECO:0000269PubMed:22681888}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:20402667}. Note=Peaks in interphase, with relatively low levels maintained throughout mitosis. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in testis. Expressed at high levels in T-cell acute lymphoblastic leukemia. {ECO:0000269PubMed:14715245, ECO:0000269PubMed:21853124}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006511
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ubiquitin-dependent protein catabolic process
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GO:0007067
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mitotic nuclear division
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GO:0016579
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protein deubiquitination
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GO:0043161
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proteasome-mediated ubiquitin-dependent protein catabolic process
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GO:0051322
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anaphase
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GO:0060564
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negative regulation of mitotic anaphase-promoting complex activity
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GO:0090231
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regulation of spindle checkpoint
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GO:0090266
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regulation of mitotic cell cycle spindle assembly checkpoint
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Cellular Component |
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PDB ID |
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InterPro |
IPR001394
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR001607
Zinc finger, UBP-type
IPR028889
Ubiquitin carboxyl-terminal hydrolase-like domain
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PFAM |
PF00443
PF02148
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PRINTS |
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PIRSF |
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SMART |
SM00290
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H0E7
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PhosphoSite |
PhosphoSite-Q9H0E7
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TrEMBL |
F8VVD6
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UniProt Splice Variant |
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Entrez Gene |
84101
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UniGene |
Hs.736443
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RefSeq |
NP_001265322
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HUGO |
HGNC:20064
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OMIM |
610993
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CCDS |
CCDS9053
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HPRD |
15636
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IMGT |
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EMBL |
AC018475
AK315697
AL136825
BC030704
CH471054
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GenPept |
AAH30704
BAG38060
CAB66759
EAW97540
EAW97541
EAW97542
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