InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF202

Summary

InnateDB Protein

IDBP-583730.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF202

Protein Name

zinc finger protein 202

Synonyms

ZKSCAN10; ZSCAN42;

Species

Homo sapiens

Ensembl Protein

ENSP00000432504

InnateDB Gene

IDBG-74915 (ZNF202)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Highly expressed in testis. Also expressed in breast carcinoma cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006629	lipid metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001909 Krueppel-associated box
IPR003309 Transcription regulator SCAN
IPR007087 Zinc finger, C2H2
IPR008916 Retrovirus capsid, C-terminal
IPR015880 Zinc finger, C2H2-like

PFAM

PF01352
PF02023
PF00096

PRINTS

PIRSF

SMART

SM00349
SM00431
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95125