InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMAD3

Summary

InnateDB Protein

IDBP-583751.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMAD3

Protein Name

SMAD family member 3

Synonyms

HSPC193; HsT17436; JV15-2; LDS1C; LDS3; MADH3;

Species

Homo sapiens

Ensembl Protein

ENSP00000445348

InnateDB Gene

IDBG-18366 (SMAD3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 529 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Experimentally validated
Total	529 [view]
Protein-Protein	508 [view]
Protein-DNA	16 [view]
Protein-RNA	0
DNA-DNA	5 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0000988	protein binding transcription factor activity
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005160	transforming growth factor beta receptor binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0019901	protein kinase binding
GO:0019902	phosphatase binding
GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0031625	ubiquitin protein ligase binding
GO:0035326	enhancer binding
GO:0042803	protein homodimerization activity
GO:0043130	ubiquitin binding
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0070410	co-SMAD binding
GO:0070412	R-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001666	response to hypoxia
GO:0001933	negative regulation of protein phosphorylation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006810	transport
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006955	immune response
GO:0007050	cell cycle arrest
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007183	SMAD protein complex assembly
GO:0010467	gene expression
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0019049	evasion or tolerance of host defenses by virus
GO:0030308	negative regulation of cell growth
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031053	primary miRNA processing
GO:0032909	regulation of transforming growth factor beta2 production
GO:0032924	activin receptor signaling pathway
GO:0035413	positive regulation of catenin import into nucleus
GO:0035556	intracellular signal transduction
GO:0038092	nodal signaling pathway
GO:0042060	wound healing
GO:0042177	negative regulation of protein catabolic process
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0045216	cell-cell junction organization
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045930	negative regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050821	protein stabilization
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:1901313	positive regulation of gene expression involved in extracellular matrix organization

Cellular Component

GO:0000790	nuclear chromatin
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005637	nuclear inner membrane
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043235	receptor complex
GO:0071141	SMAD protein complex
GO:0071144	SMAD2-SMAD3 protein complex