InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCO2

Summary

InnateDB Protein

IDBP-584007.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCO2

Protein Name

beta-carotene oxygenase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000436615

InnateDB Gene

IDBG-71455 (BCO2)

Protein Structure

UniProt Annotation

Function

Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects. {ECO:0000269PubMed:21106934}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:21106934}.

Disease Associations

Tissue Specificity

Highly expressed in retinal pigment epithelium. Also expressed in stomach, small intestine, liver, testis, kidney, adrenal gland, pancreas, heart, skeletal muscle and prostate (at protein level). {ECO:0000269PubMed:15983114}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872	metal ion binding

Biological Process

GO:0016116	carotenoid metabolic process
GO:0016119	carotene metabolic process
GO:0016121	carotene catabolic process
GO:0042573	retinoic acid metabolic process
GO:0042574	retinal metabolic process
GO:0051881	regulation of mitochondrial membrane potential
GO:0055114	oxidation-reduction process
GO:2000377	regulation of reactive oxygen species metabolic process