InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PGLYRP1

Summary

InnateDB Protein

IDBP-58415.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGLYRP1

Protein Name

peptidoglycan recognition protein 1

Synonyms

PGLYRP; PGRP; PGRP-S; PGRPS; TAG7; TNFSF3L;

Species

Homo sapiens

Ensembl Protein

ENSP00000008938

InnateDB Gene

IDBG-58413 (PGLYRP1)

Protein Structure

UniProt Annotation

Function

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity. {ECO:0000269PubMed:11461926, ECO:0000269PubMed:16354652}.

Subcellular Localization

Secreted {ECO:0000269PubMed:16354652}. Cytoplasmic granule {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in bone marrow. Weak expression found in kidney, liver, small intestine, spleen, thymus, peripheral leukocyte, lung, fetal spleen and neutrophils. {ECO:0000269PubMed:11461926, ECO:0000269PubMed:9707603}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity
GO:0016019	peptidoglycan receptor activity
GO:0042834	peptidoglycan binding

Biological Process

GO:0002221	pattern recognition receptor signaling pathway
GO:0006955	immune response
GO:0009253	peptidoglycan catabolic process
GO:0016045	detection of bacterium
GO:0032689	negative regulation of interferon-gamma production
GO:0032827	negative regulation of natural killer cell differentiation involved in immune response
GO:0044117	growth of symbiont in host
GO:0045087	innate immune response (InnateDB)
GO:0050728	negative regulation of inflammatory response
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0005576	extracellular region
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002502 N-acetylmuramoyl-L-alanine amidase domain
IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria
IPR017331 Peptidoglycan recognition protein, PGRP-S

PFAM

PF01510

PRINTS

PIRSF

PIRSF037945

SMART

SM00644
SM00701

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt