Version 5.4
Homo sapiens Protein: REG1A
Summary
InnateDB Protein IDBP-58454.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol REG1A
Protein Name regenerating islet-derived 1 alpha
Synonyms ICRF; P19; PSP; PSPS; PSPS1; PTP; REG;
Species Homo sapiens
Ensembl Protein ENSP00000233735
InnateDB Gene IDBG-58452 (REG1A)
Protein Structure
UniProt Annotation
Function Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity In pancreatic acinar cells and, in lower levels, in brain. Enhanced expression of PSP-related transcripts and intraneuronal accumulation of PSP-like proteins is found in brain from Alzheimer disease and Down syndrome patients. {ECO:0000269PubMed:2394826}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008083 growth factor activity
GO:0030246 carbohydrate binding
Biological Process
GO:0008284 positive regulation of cell proliferation
Cellular Component
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR002353 Type-2 ice-structuring protein
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS PR00356
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P05451
PhosphoSite PhosphoSite-P05451
TrEMBL Q2TBE1
UniProt Splice Variant
Entrez Gene 5967
UniGene Hs.49407
RefSeq NP_002900
HUGO HGNC:9951
OMIM 167770
CCDS CCDS1964
HPRD 01338
IMGT
EMBL AC017004 AF172331 BC005350 BC110438 BC118621 CH471053 J05412 M18963 M27189 M27190
GenPept AAA36558 AAA36559 AAA60545 AAA60546 AAD51330 AAH05350 AAI10439 AAI18622 AAX88842 EAW99576 EAW99578

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca