Version 5.4
Homo sapiens Protein: CRB2
Summary
InnateDB Protein IDBP-584837.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRB2
Protein Name crumbs homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000435279
InnateDB Gene IDBG-84570 (CRB2)
Protein Structure
UniProt Annotation
Function May play a role in polarized cells morphogenesis.
Subcellular Localization Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.
Disease Associations
Tissue Specificity Expressed in retina, fetal eye and brain. Also expressed in kidney, ARPE-19 and RPE/choroid cell lines, and at low levels in lung, placenta, and heart. {ECO:0000269PubMed:15851977}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019828 aspartic-type endopeptidase inhibitor activity
GO:0019899 enzyme binding
Biological Process
GO:0001707 mesoderm formation
GO:0001756 somitogenesis
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010951 negative regulation of endopeptidase activity
GO:0014028 notochord formation
GO:0030513 positive regulation of BMP signaling pathway
GO:0045199 maintenance of epithelial cell apical/basal polarity
GO:0072358 cardiovascular system development
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043234 protein complex
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF00008
PF00054
PF02210
PF07645
PRINTS
PIRSF
SMART SM00181
SM00210
SM00282
SM00179
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5IJ48
PhosphoSite PhosphoSite-Q5IJ48
TrEMBL
UniProt Splice Variant
Entrez Gene 286204
UniGene Hs.710092
RefSeq
HUGO HGNC:18688
OMIM 609720
CCDS
HPRD 13093
IMGT
EMBL AK123000 AK126775 AL365504 AL445489 AY720432 DQ426866
GenPept AAU14134 ABD90532 BAC86684 CAI39793 CAI41011 CAM14433 CAM21391

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca