Version 5.4
Homo sapiens Protein: MED6
Summary
InnateDB Protein IDBP-584907.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED6
Protein Name mediator complex subunit 6
Synonyms ARC33; NY-REN-28;
Species Homo sapiens
Ensembl Protein ENSP00000451684
InnateDB Gene IDBG-10785 (MED6)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 75 [view]
Protein-Protein 75 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0008134 transcription factor binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0016592 mediator complex
Protein Structure and Domains
PDB ID
InterPro IPR007018 Mediator complex, subunit Med6
IPR016820 Mediator complex, subunit Med6, metazoa/plant
PFAM PF04934
PRINTS
PIRSF PIRSF023869
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3V4A5
UniProt Splice Variant
Entrez Gene 10001
UniGene Hs.497353
RefSeq
HUGO HGNC:19970
OMIM 602984
CCDS
HPRD 04284
IMGT
EMBL AF074723 AF155104 AK222587 AK223346 AK300460 AK304361 AL357153 BC004106 BT006831 CR541697 U78082
GenPept AAB84363 AAC26869 AAD42870 AAH04106 AAP35477 BAD96307 BAD97066 BAG62179 BAG65202 CAG46498

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca