InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGS6

Summary

InnateDB Protein

IDBP-585210.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS6

Protein Name

regulator of G-protein signaling 6

Synonyms

GAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000451030

InnateDB Gene

IDBG-11010 (RGS6)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer. {ECO:0000269PubMed:10521509}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity
GO:0045666	positive regulation of neuron differentiation

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000342 Regulator of G protein signalling domain
IPR000591 DEP domain
IPR015898 G-protein gamma-like domain
IPR016137 Regulator of G protein signalling superfamily

PFAM

PF00615
PF00610
PF00631

PRINTS

PR01301

PIRSF

SMART

SM00049
SM00224
SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt