Version 5.4
Homo sapiens Protein: APEX1
Summary
InnateDB Protein IDBP-585243.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APEX1
Protein Name APEX nuclease (multifunctional DNA repair enzyme) 1
Synonyms APE; APE1; APEN; APEX; APX; HAP1; REF1;
Species Homo sapiens
Ensembl Protein ENSP00000452418
InnateDB Gene IDBG-2246 (APEX1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 88 [view]
Protein-Protein 83 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
Biological Process
GO:0006281 DNA repair
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID
InterPro IPR004808 AP endonuclease 1
IPR005135 Endonuclease/exonuclease/phosphatase
PFAM PF03372
PF14529
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3V5M0
UniProt Splice Variant
Entrez Gene 328
UniGene Hs.73722
RefSeq
HUGO HGNC:587
OMIM 107748
CCDS
HPRD 00136
IMGT
EMBL AL355075
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca