InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOCS4

Summary

InnateDB Protein

IDBP-585339.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOCS4

Protein Name

suppressor of cytokine signaling 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000452522

InnateDB Gene

IDBG-7209 (SOCS4)

Protein Structure

UniProt Annotation

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. {ECO:0000269PubMed:15590694, ECO:0000269PubMed:17997974}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0007175	negative regulation of epidermal growth factor-activated receptor activity
GO:0016567	protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035556	intracellular signal transduction
GO:0040008	regulation of growth