Version 5.4
Homo sapiens Protein: PRR5L
Summary
InnateDB Protein IDBP-585734.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRR5L
Protein Name proline rich 5 like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000435050
InnateDB Gene IDBG-40053 (PRR5L)
Protein Structure
UniProt Annotation
Function Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton. Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration. {ECO:0000269PubMed:17461779, ECO:0000269PubMed:22609986}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0009968 negative regulation of signal transduction
GO:0010762 regulation of fibroblast migration
GO:0038203 TORC2 signaling
Cellular Component
GO:0031932 TORC2 complex
Protein Structure and Domains
PDB ID
InterPro IPR013745 HbrB-like
PFAM PF08539
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6MZQ0
PhosphoSite PhosphoSite-Q6MZQ0
TrEMBL E9PS02
UniProt Splice Variant
Entrez Gene 79899
UniGene Hs.609771
RefSeq NP_001153639
HUGO HGNC:25878
OMIM 611728
CCDS CCDS31463
HPRD 07854
IMGT
EMBL AC009656 AC087277 AK024275 BC008922 BC125122 BX640959 CH471064 DR001466
GenPept AAH08922 AAI25123 BAB14870 CAE45978 EAW68124

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca