InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PC

Summary

InnateDB Protein

IDBP-586029.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

pyruvate carboxylase

Synonyms

PCB;

Species

Homo sapiens

Ensembl Protein

ENSP00000434192

InnateDB Gene

IDBG-59727 (PC)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004075	biotin carboxylase activity
GO:0005524	ATP binding
GO:0008716	D-alanine-D-alanine ligase activity
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0008152

metabolic process

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR003135 ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
IPR005482 Biotin carboxylase, C-terminal
IPR011054 Rudiment single hybrid motif
IPR011095 D-alanine--D-alanine ligase, C-terminal
IPR011761 ATP-grasp fold
IPR011764 Biotin carboxylation domain
IPR013651 ATP-grasp fold, RimK-type
IPR016185 Pre-ATP-grasp domain

PFAM

PF02222
PF02786
PF00289
PF02785
PF07478
PF08443

PRINTS

PIRSF

SMART

SM00878

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite