Version 5.4
Homo sapiens Protein: SERPINA12
Summary
InnateDB Protein IDBP-586717.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINA12
Protein Name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000451738
InnateDB Gene IDBG-18314 (SERPINA12)
Protein Structure
UniProt Annotation
Function Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. {ECO:0000269PubMed:16030142}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed in visceral adipose tissues. {ECO:0000269PubMed:16030142}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IW75
PhosphoSite PhosphoSite-Q8IW75
TrEMBL
UniProt Splice Variant
Entrez Gene 145264
UniGene Hs.99476
RefSeq XP_005267408
HUGO HGNC:18359
OMIM
CCDS CCDS9926
HPRD 18038
IMGT
EMBL AY177692 AY326420 BC040857
GenPept AAH40857 AAO18649 AAP88384

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca