InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPT

Summary

InnateDB Protein

IDBP-586877.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPT

Protein Name

glutamic-pyruvate transaminase (alanine aminotransferase)

Synonyms

AAT1; ALT1; GPT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000433586

InnateDB Gene

IDBG-41262 (GPT)

Protein Structure

UniProt Annotation

Function

Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Liver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue. {ECO:0000269PubMed:11863375}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004021	L-alanine:2-oxoglutarate aminotransferase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0008652	cellular amino acid biosynthetic process
GO:0009058	biosynthetic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0042853	L-alanine catabolic process
GO:0044281	small molecule metabolic process