InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BMP4

Summary

InnateDB Protein

IDBP-586888.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BMP4

Protein Name

bone morphogenetic protein 4

Synonyms

BMP2B; BMP2B1; MCOPS6; OFC11; ZYME;

Species

Homo sapiens

Ensembl Protein

ENSP00000454134

InnateDB Gene

IDBG-6966 (BMP4)

Protein Structure

UniProt Annotation

Function

Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Microphthalmia, syndromic, 6 (MCOPS6) [MIM:607932]: A disease characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. {ECO:0000269PubMed:18252212}. Note=The disease is caused by mutations affecting the gene represented in this entry.Non-syndromic orofacial cleft 11 (OFC11) [MIM:600625]: A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. {ECO:0000269PubMed:19249007}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042056	chemoattractant activity
GO:0070700	BMP receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000186	activation of MAPKK activity
GO:0001649	osteoblast differentiation
GO:0001657	ureteric bud development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001822	kidney development
GO:0001823	mesonephros development
GO:0001934	positive regulation of protein phosphorylation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001958	endochondral ossification
GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0002062	chondrocyte differentiation
GO:0002244	hematopoietic progenitor cell differentiation
GO:0002320	lymphoid progenitor cell differentiation
GO:0003130	BMP signaling pathway involved in heart induction
GO:0003139	secondary heart field specification
GO:0003197	endocardial cushion development
GO:0003279	cardiac septum development
GO:0003323	type B pancreatic cell development
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007182	common-partner SMAD protein phosphorylation
GO:0007224	smoothened signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0009791	post-embryonic development
GO:0010453	regulation of cell fate commitment
GO:0010595	positive regulation of endothelial cell migration
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010942	positive regulation of cell death
GO:0021537	telencephalon development
GO:0030198	extracellular matrix organization
GO:0030224	monocyte differentiation
GO:0030225	macrophage differentiation
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0030513	positive regulation of BMP signaling pathway
GO:0032092	positive regulation of protein binding
GO:0032967	positive regulation of collagen biosynthetic process
GO:0033085	negative regulation of T cell differentiation in thymus
GO:0033088	negative regulation of immature T cell proliferation in thymus
GO:0034504	protein localization to nucleus
GO:0035990	tendon cell differentiation
GO:0035993	deltoid tuberosity development
GO:0040007	growth
GO:0042326	negative regulation of phosphorylation
GO:0042476	odontogenesis
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043401	steroid hormone mediated signaling pathway
GO:0043407	negative regulation of MAP kinase activity
GO:0045606	positive regulation of epidermal cell differentiation
GO:0045662	negative regulation of myoblast differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045778	positive regulation of ossification
GO:0045786	negative regulation of cell cycle
GO:0045839	negative regulation of mitosis
GO:0045843	negative regulation of striated muscle tissue development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048286	lung alveolus development
GO:0048392	intermediate mesodermal cell differentiation
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048745	smooth muscle tissue development
GO:0048754	branching morphogenesis of an epithelial tube
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050918	positive chemotaxis
GO:0055020	positive regulation of cardiac muscle fiber development
GO:0060391	positive regulation of SMAD protein import into nucleus
GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395	SMAD protein signal transduction
GO:0060425	lung morphogenesis
GO:0060433	bronchus development
GO:0060438	trachea development
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0060502	epithelial cell proliferation involved in lung morphogenesis
GO:0060503	bud dilation involved in lung branching
GO:0060548	negative regulation of cell death
GO:0061036	positive regulation of cartilage development
GO:0061047	positive regulation of branching involved in lung morphogenesis
GO:0061149	BMP signaling pathway involved in ureter morphogenesis
GO:0061151	BMP signaling pathway involved in renal system segmentation
GO:0061155	pulmonary artery endothelial tube morphogenesis
GO:0070244	negative regulation of thymocyte apoptotic process
GO:0071893	BMP signaling pathway involved in nephric duct formation
GO:0072001	renal system development
GO:0072097	negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
GO:0072101	specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
GO:0072104	glomerular capillary formation
GO:0072125	negative regulation of glomerular mesangial cell proliferation
GO:0072192	ureter epithelial cell differentiation
GO:0072193	ureter smooth muscle cell differentiation
GO:0072200	negative regulation of mesenchymal cell proliferation involved in ureter development
GO:0072205	metanephric collecting duct development
GO:0090184	positive regulation of kidney development
GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis
GO:0090194	negative regulation of glomerulus development
GO:2000005	negative regulation of metanephric S-shaped body morphogenesis
GO:2000007	negative regulation of metanephric comma-shaped body morphogenesis
GO:2000105	positive regulation of DNA-dependent DNA replication
GO:2000137	negative regulation of cell proliferation involved in heart morphogenesis