InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPAS3

Summary

InnateDB Protein

IDBP-588545.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPAS3

Protein Name

neuronal PAS domain protein 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000449542

InnateDB Gene

IDBG-4493 (NPAS3)

Protein Structure

UniProt Annotation

Function

May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981, ECO:0000269PubMed:12746393}.

Disease Associations

Note=A chromosomal aberration involving NPAS3 is found in a family with schizophrenia. Translocation t(9;14)(q34;q13).

Tissue Specificity

Ubiquitously expressed in the adult brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004871	signal transducer activity
GO:0046983	protein dimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0045893	positive regulation of transcription, DNA-templated