InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LHX5

Summary

InnateDB Protein

IDBP-58870.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LHX5

Protein Name

LIM homeobox 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000261731

InnateDB Gene

IDBG-58868 (LHX5)

Protein Structure

UniProt Annotation

Function

Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in fetal brain and in various regions of the adult central nervous system including the spinal cord, the thalamus, and the cerebellum.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007267	cell-cell signaling
GO:0021527	spinal cord association neuron differentiation
GO:0021549	cerebellum development
GO:0021702	cerebellar Purkinje cell differentiation
GO:0021766	hippocampus development
GO:0021846	cell proliferation in forebrain
GO:0021879	forebrain neuron differentiation
GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
GO:0042127	regulation of cell proliferation
GO:0045893	positive regulation of transcription, DNA-templated