InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TWF1

Summary

InnateDB Protein

IDBP-588701.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TWF1

Protein Name

twinfilin, actin-binding protein, homolog 1 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000448750

InnateDB Gene

IDBG-28090 (TWF1)

Protein Structure

UniProt Annotation

Function

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver. {ECO:0000269PubMed:7507208}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0003785	actin monomer binding
GO:0005524	ATP binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding

Biological Process

GO:0030837	negative regulation of actin filament polymerization
GO:0042989	sequestering of actin monomers
GO:0043538	regulation of actin phosphorylation

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005911	cell-cell junction
GO:0015629	actin cytoskeleton
GO:0030016	myofibril
GO:0030175	filopodium
GO:0032587	ruffle membrane
GO:0048471	perinuclear region of cytoplasm