InnateDB Protein
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IDBP-588705.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NACA
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Protein Name
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nascent polypeptide-associated complex alpha subunit
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Synonyms
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NACA1; skNAC;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000447821
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InnateDB Gene
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IDBG-41511 (NACA)
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Protein Structure
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Function |
Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. {ECO:0000269PubMed:10982809, ECO:0000269PubMed:15784678, ECO:0000269PubMed:9877153}.
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Subcellular Localization |
Cytoplasm. Nucleus. Note=The heterodimer is located mainly in the cytosol, and the homodimer in the nucleus.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:16201836}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
42
[view]
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Protein-Protein |
40
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
GO:0003231
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cardiac ventricle development
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GO:0006351
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transcription, DNA-templated
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GO:0006412
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translation
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GO:0010664
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negative regulation of striated muscle cell apoptotic process
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GO:0015031
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protein transport
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GO:0016032
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viral process
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GO:0043403
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skeletal muscle tissue regeneration
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GO:0048633
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positive regulation of skeletal muscle tissue growth
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GO:0048742
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regulation of skeletal muscle fiber development
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GO:0061384
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heart trabecula morphogenesis
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GO:1901227
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negative regulation of transcription from RNA polymerase II promoter involved in heart development
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GO:1901228
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positive regulation of transcription from RNA polymerase II promoter involved in heart development
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GO:2000138
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positive regulation of cell proliferation involved in heart morphogenesis
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Cellular Component |
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PDB ID |
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InterPro |
IPR002715
Nascent polypeptide-associated complex NAC domain
IPR009060
UBA-like
IPR016641
Nascent polypeptide-associated complex subunit alpha
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PFAM |
PF01849
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PRINTS |
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PIRSF |
PIRSF015901
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q13765
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PhosphoSite |
PhosphoSite-
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TrEMBL |
F8W1N5
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UniProt Splice Variant |
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Entrez Gene |
4666
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UniGene |
Hs.732910
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RefSeq |
XP_006719481
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HUGO |
HGNC:7629
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OMIM |
601234
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CCDS |
CCDS31837
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HPRD |
03137
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IMGT |
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EMBL |
AC117378
AF054187
AK090650
AK223085
AK311904
AY034001
AY605660
AY911673
BC105120
BC105122
BC106041
CH471054
CR450295
X80909
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GenPept |
AAC99403
AAI05121
AAI05123
AAI06042
AAK57544
AAV83778
AAX14393
BAD96805
BAG34845
BAG52208
CAA56869
CAG29291
EAW96960
EAW96961
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