Version 5.4
Homo sapiens Protein: DIO2
Summary
InnateDB Protein IDBP-588732.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DIO2
Protein Name deiodinase, iodothyronine, type II
Synonyms 5DII; D2; DIOII; SelY; TXDI2;
Species Homo sapiens
Ensembl Protein ENSP00000451136
InnateDB Gene IDBG-14346 (DIO2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004800 thyroxine 5'-deiodinase activity
Biological Process
GO:0042446 hormone biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000643 Iodothyronine deiodinase
PFAM PF00837
PRINTS
PIRSF PIRSF001330
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3V3A8
UniProt Splice Variant
Entrez Gene 1734
UniGene Hs.732170
RefSeq
HUGO HGNC:2884
OMIM 601413
CCDS
HPRD 09027
IMGT
EMBL AC007372 AC010849 AL049837
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca