InnateDB Protein
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IDBP-58879.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RBM19
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Protein Name
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RNA binding motif protein 19
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000261741
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InnateDB Gene
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IDBG-58877 (RBM19)
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Protein Structure
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Function |
Plays a role in embryo pre-implantation development. {ECO:0000250}.
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Subcellular Localization |
Nucleus, nucleolus {ECO:0000269PubMed:12429849, ECO:0000269PubMed:16027046}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Chromosome {ECO:0000250}. Note=In discrete foci distributed throughout the cytoplasm and nucleoplasm during the 4 to 8 cell stages and the morula stage, but not in the periphery of the nucleolar precursor body (NPB). During blastocyst development, becomes increasingly localized to the nucleolus and less to the cytoplasm. At the late blastocyst stage, localized predominantly in the nucleolus. Localized in the nucleolus during interphase and to the perichromosomal sheath during mitosis. Does not colocalize in the cytoplasm with GW182 in P-bodies. May translocate to the nucleolus upon early embryonic development (By similarity). Colocalizes with NPM1 during interphase. By late prophase, metaphase, anaphase and telophase, associates with the chromosome periphery. By telophase localizes to NPB. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in the crypts of Lieberkuhn of the intestine and in intestinal neoplasia (at protein level). {ECO:0000269PubMed:16027046}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0007275
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multicellular organismal development
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GO:0040019
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positive regulation of embryonic development
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
IPR003954
RNA recognition motif domain, eukaryote
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
SM00361
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y4C8
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PhosphoSite |
PhosphoSite-Q9Y4C8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9904
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UniGene |
Hs.7482
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RefSeq |
NP_057280
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HUGO |
HGNC:29098
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OMIM |
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CCDS |
CCDS9172
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HPRD |
15225
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IMGT |
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EMBL |
AB014582
AC009731
AC073863
AC090669
AK291444
AK314606
AL117547
BC004289
BC006137
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GenPept |
AAH04289
AAH06137
BAA31657
BAF84133
BAG37176
CAB55987
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