InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL12RB2

Summary

InnateDB Protein

IDBP-588861.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL12RB2

Protein Name

interleukin 12 receptor, beta 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000445276

InnateDB Gene

IDBG-99563 (IL12RB2)

Protein Structure

UniProt Annotation

Function

Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Isoform 2 is expressed at similar levels in both naive and activated T-cells. {ECO:0000269PubMed:9120388}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0005515	protein binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0019221	cytokine-mediated signaling pathway
GO:0032729	positive regulation of interferon-gamma production