InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNG8

Summary

InnateDB Protein

IDBP-58888.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNG8

Protein Name

guanine nucleotide binding protein (G protein), gamma 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000300873

InnateDB Gene

IDBG-58886 (GNG8)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006184	GTP catabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007399	nervous system development
GO:0044281	small molecule metabolic process
GO:0071377	cellular response to glucagon stimulus