InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AIFM1

Summary

InnateDB Protein

IDBP-589174.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AIFM1

Protein Name

apoptosis-inducing factor, mitochondrion-associated, 1

Synonyms

AIF; CMT2D; CMTX4; COWCK; COXPD6; NADMR; NAMSD; PDCD8;

Species

Homo sapiens

Ensembl Protein

ENSP00000446113

InnateDB Gene

IDBG-85972 (AIFM1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	72 [view]
Protein-Protein	70 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0016174	NAD(P)H oxidase activity
GO:0016491	oxidoreductase activity
GO:0016651	oxidoreductase activity, acting on NAD(P)H
GO:0046983	protein dimerization activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006308	DNA catabolic process
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0030182	neuron differentiation
GO:0030261	chromosome condensation
GO:0032981	mitochondrial respiratory chain complex I assembly
GO:0043065	positive regulation of apoptotic process
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0005829	cytosol
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM

PF07992

PRINTS

PR00368

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95831