InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EVI5

Summary

InnateDB Protein

IDBP-589290.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EVI5

Protein Name

ecotropic viral integration site 5

Synonyms

NB4S;

Species

Homo sapiens

Ensembl Protein

ENSP00000440826

InnateDB Gene

IDBG-100285 (EVI5)

Protein Structure

UniProt Annotation

Function

Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis. {ECO:0000269PubMed:16439210}.

Subcellular Localization

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis.

Disease Associations

Note=A chromosomal aberration involving EVI5 is found is a patient with stage 4S neuroblastoma. Translocation t(1;10)(p22;q21) that forms a EVI5-TRNG10 fusion protein. TRNG10 is a probable structural transcript which is normally not translated. {ECO:0000269PubMed:9618176}.

Tissue Specificity

Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal. {ECO:0000269PubMed:16033705, ECO:0000269PubMed:9618176}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005097	Rab GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0007049	cell cycle
GO:0007275	multicellular organismal development
GO:0008283	cell proliferation
GO:0032313	regulation of Rab GTPase activity
GO:0032851	positive regulation of Rab GTPase activity
GO:0051301	cell division