Version 5.4
Homo sapiens Protein: HAL
Summary
InnateDB Protein IDBP-589414.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HAL
Protein Name histidine ammonia-lyase
Synonyms HIS; HSTD;
Species Homo sapiens
Ensembl Protein ENSP00000440861
InnateDB Gene IDBG-51903 (HAL)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 3 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004397 histidine ammonia-lyase activity
GO:0016841 ammonia-lyase activity
Biological Process
GO:0006548 histidine catabolic process
GO:0009058 biosynthetic process
GO:0019556 histidine catabolic process to glutamate and formamide
GO:0019557 histidine catabolic process to glutamate and formate
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR001106 Aromatic amino acid lyase
IPR005921 Histidine ammonia-lyase
IPR008948 L-Aspartase-like
PFAM PF00221
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P42357
PhosphoSite PhosphoSite-P42357
TrEMBL Q2PH61
UniProt Splice Variant
Entrez Gene 3034
UniGene Hs.742210
RefSeq NP_001245263
HUGO HGNC:4806
OMIM 609457
CCDS CCDS58265
HPRD 07187
IMGT
EMBL AB042217 AB191160 AB191161 AB191162 AB191166 AC007298 AC126174 AK298736 AK303544 BC096097 BC096098 BC096099 CH471054 D16626
GenPept AAH96097 AAH96098 AAH96099 BAA04047 BAB61863 BAE72109 BAE72110 BAE72111 BAE72115 BAG60883 BAG64570 EAW97556

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca