InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSTM3

Summary

InnateDB Protein

IDBP-589564.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSTM3

Protein Name

glutathione S-transferase mu 3 (brain)

Synonyms

GST5; GSTB; GSTM3-3; GTM3;

Species

Homo sapiens

Ensembl Protein

ENSP00000444978

InnateDB Gene

IDBG-100908 (GSTM3)

Protein Structure

UniProt Annotation

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers. {ECO:0000269PubMed:10587441}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Testis and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043295	glutathione binding

Biological Process

GO:0006749	glutathione metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008065	establishment of blood-nerve barrier
GO:0018916	nitrobenzene metabolic process
GO:0042178	xenobiotic catabolic process
GO:0043627	response to estrogen
GO:0044281	small molecule metabolic process
GO:0070458	cellular detoxification of nitrogen compound
GO:1901687	glutathione derivative biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003081 Glutathione S-transferase, Mu class
IPR004045 Glutathione S-transferase, N-terminal
IPR004046 Glutathione S-transferase, C-terminal
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM