InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANGPT2

Summary

InnateDB Protein

IDBP-5899.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANGPT2

Protein Name

angiopoietin 2

Synonyms

AGPT2; ANG2;

Species

Homo sapiens

Ensembl Protein

ENSP00000343517

InnateDB Gene

IDBG-5893 (ANGPT2)

Protein Structure

UniProt Annotation

Function

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. {ECO:0000269PubMed:15284220, ECO:0000269PubMed:19116766, ECO:0000269PubMed:19223473, ECO:0000269PubMed:9204896}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0030971	receptor tyrosine kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0048014	Tie signaling pathway
GO:0050900	leukocyte migration
GO:0050928	negative regulation of positive chemotaxis
GO:0072012	glomerulus vasculature development