Version 5.4
Homo sapiens Protein: YAP1
Summary
InnateDB Protein IDBP-590100.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YAP1
Protein Name Yes-associated protein 1
Synonyms COB1; YAP; YAP2; YAP65; YKI;
Species Homo sapiens
Ensembl Protein ENSP00000434134
InnateDB Gene IDBG-68995 (YAP1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 161 [view]
Protein-Protein 158 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006974 cellular response to DNA damage stimulus
GO:0008283 cell proliferation
GO:0010467 gene expression
GO:0035329 hippo signaling
GO:0060242 contact inhibition
GO:0071480 cellular response to gamma radiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR001202 WW domain
PFAM PF00397
PRINTS
PIRSF
SMART SM00456
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P46937
PhosphoSite PhosphoSite-P46937
TrEMBL A0A024R3E4
UniProt Splice Variant
Entrez Gene 10413
UniGene Hs.737025
RefSeq NP_006097
HUGO HGNC:16262
OMIM 606608
CCDS CCDS8314
HPRD 09424
IMGT
EMBL AB567720 AB567721 AK300414 AK316116 AP000942 AP001527 AP002777 AY316529 BC038235 CH471065 HE864159 HE864160 HE864161 HE864162 X80507
GenPept AAH38235 AAP92710 BAG62143 BAH14487 BAJ41471 BAJ41472 CAA56672 CCI79618 CCI79619 CCI79620 CCI79621 EAW67011 EAW67012 EAW67014 EAW67015

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca