InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MSH2

Summary

InnateDB Protein

IDBP-590168.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MSH2

Protein Name

mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)

Synonyms

COCA1; FCC1; HNPCC; HNPCC1; LCFS2;

Species

Homo sapiens

Ensembl Protein

ENSP00000442697

InnateDB Gene

IDBG-50900 (MSH2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 130 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	132 [view]
Protein-Protein	132 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0000400	four-way junction DNA binding
GO:0000403	Y-form DNA binding
GO:0000404	heteroduplex DNA loop binding
GO:0000406	double-strand/single-strand DNA junction binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008094	DNA-dependent ATPase activity
GO:0016887	ATPase activity
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0030983	mismatched DNA binding
GO:0032137	guanine/thymine mispair binding
GO:0032139	dinucleotide insertion or deletion binding
GO:0032142	single guanine insertion binding
GO:0032143	single thymine insertion binding
GO:0032181	dinucleotide repeat insertion binding
GO:0032357	oxidized purine DNA binding
GO:0032405	MutLalpha complex binding
GO:0042803	protein homodimerization activity
GO:0043531	ADP binding

Biological Process

GO:0000710	meiotic mismatch repair
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0006301	postreplication repair
GO:0006302	double-strand break repair
GO:0006311	meiotic gene conversion
GO:0008584	male gonad development
GO:0010165	response to X-ray
GO:0010224	response to UV-B
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0016447	somatic recombination of immunoglobulin gene segments
GO:0019724	B cell mediated immunity
GO:0030183	B cell differentiation
GO:0031573	intra-S DNA damage checkpoint
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043524	negative regulation of neuron apoptotic process
GO:0043570	maintenance of DNA repeat elements
GO:0045128	negative regulation of reciprocal meiotic recombination
GO:0045190	isotype switching
GO:0045910	negative regulation of DNA recombination
GO:0051096	positive regulation of helicase activity

Cellular Component

GO:0000228	nuclear chromosome
GO:0016020	membrane
GO:0032301	MutSalpha complex
GO:0032302	MutSbeta complex

Protein Structure and Domains

PDB ID

InterPro

IPR000432 DNA mismatch repair protein MutS, C-terminal
IPR007695 DNA mismatch repair protein MutS-like, N-terminal
IPR007696 DNA mismatch repair protein MutS, core
IPR007860 DNA mismatch repair protein MutS, connector domain
IPR007861 DNA mismatch repair protein MutS, clamp
IPR011184 DNA mismatch repair protein, MSH2
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00488
PF01624
PF05192
PF05188
PF05190

PRINTS

PIRSF

PIRSF005813

SMART

SM00534
SM00533

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt