InnateDB Protein
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IDBP-590420.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CLEC5A
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Protein Name
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C-type lectin domain family 5, member A
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Synonyms
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CLECSF5; MDL-1; MDL1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000449999
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InnateDB Gene
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IDBG-546985 (CLEC5A)
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Protein Structure
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Function |
Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release. {ECO:0000250, ECO:0000269PubMed:10449773, ECO:0000269PubMed:18496526}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:21566123}; Single-pass type II membrane protein {ECO:0000269PubMed:21566123}.
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Disease Associations |
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Tissue Specificity |
Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells. {ECO:0000269PubMed:10449773}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001304
C-type lectin
IPR016187
C-type lectin fold
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PFAM |
PF00059
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PRINTS |
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PIRSF |
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SMART |
SM00034
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NY25
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PhosphoSite |
PhosphoSite-
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TrEMBL |
A4D1U7
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UniProt Splice Variant |
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Entrez Gene |
23601
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UniGene |
Hs.446235
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RefSeq |
NP_037384
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HUGO |
HGNC:2054
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OMIM |
604987
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CCDS |
CCDS5870
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HPRD |
09229
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IMGT |
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EMBL |
AC073647
AF139768
AJ271684
AK292766
AK313703
BC093714
BC112099
BC113098
CH236950
CH471070
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GenPept |
AAF02491
AAH93714
AAI12100
AAI13099
AAS07444
BAF85455
BAG36449
CAB71334
EAL24012
EAW83992
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