Version 5.4
Homo sapiens Protein: ZFYVE1
Summary
InnateDB Protein IDBP-590499.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFYVE1
Protein Name zinc finger, FYVE domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000450742
InnateDB Gene IDBG-11183 (ZFYVE1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Golgi apparatus, Golgi stack. Endoplasmic reticulum. Note=Resides predominantly in the cisternal stacks of the Golgi. Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum.
Disease Associations
Tissue Specificity Isoform 1 is expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Isoform 1 and isoform 2 are highly expressed in heart. Isoform 2 is also detected in the testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005545 1-phosphatidylinositol binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008270 zinc ion binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0046872 metal ion binding
Biological Process
GO:0010923 negative regulation of phosphatase activity
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005795 Golgi stack
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000306 FYVE zinc finger
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF01363
PRINTS
PIRSF
SMART SM00064
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HBF4
PhosphoSite PhosphoSite-Q9HBF4
TrEMBL
UniProt Splice Variant
Entrez Gene 53349
UniGene Hs.335106
RefSeq NP_067083
HUGO HGNC:13180
OMIM 605471
CCDS CCDS9811
HPRD 12017
IMGT
EMBL AB046809 AF251025 AF311602 AF318319 AJ310569 AK027399 AL442663 BC053520
GenPept AAG23748 AAH53520 AAK27339 AAL55826 BAB13415 BAB55085 CAC83950

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca