InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NAALAD2

Summary

InnateDB Protein

IDBP-590843.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAALAD2

Protein Name

N-acetylated alpha-linked acidic dipeptidase 2

Synonyms

GCPIII; GPCIII; NAADALASE2; NAALADASE2;

Species

Homo sapiens

Ensembl Protein

ENSP00000432481

InnateDB Gene

IDBG-67697 (NAALAD2)

Protein Structure

UniProt Annotation

Function

Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivate the peptide neurotransmitter N- acetylaspartylglutamate. {ECO:0000269PubMed:10085079}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Highest expression in the testis. Also found in ovary and spleen. Weak expression in prostate, heart and placenta. In brain, expressed in striatum, parietal cortex and ventral striatum with lower levels in hippocampus, brain stem, putamen and superior colliculus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004180	carboxypeptidase activity
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0008237	metallopeptidase activity
GO:0008239	dipeptidyl-peptidase activity
GO:0016805	dipeptidase activity
GO:0046872	metal ion binding
GO:0050129	N-formylglutamate deformylase activity