InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFATC4

Summary

InnateDB Protein

IDBP-591286.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFATC4

Protein Name

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

Synonyms

NF-AT3; NF-ATC4; NFAT3;

Species

Homo sapiens

Ensembl Protein

ENSP00000450469

InnateDB Gene

IDBG-3927 (NFATC4)

Protein Structure

UniProt Annotation

Function

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL- 4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons. {ECO:0000269PubMed:11997522, ECO:0000269PubMed:17213202, ECO:0000269PubMed:18668201, ECO:0000269PubMed:7749981}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18347059}. Nucleus {ECO:0000269PubMed:18347059}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.

Disease Associations

Tissue Specificity

Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus. {ECO:0000269PubMed:18675896}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	26 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006954	inflammatory response
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0045111	intermediate filament cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR002909 IPT domain
IPR008366 Nuclear factor of activated T cells (NFAT)
IPR008967 p53-like transcription factor, DNA-binding
IPR011539 Rel homology domain
IPR014756 Immunoglobulin E-set

PFAM

PF01833
PF00554

PRINTS

PR01789

PIRSF

SMART

SM00429

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt