InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SETDB1

Summary

InnateDB Protein

IDBP-591806.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SETDB1

Protein Name

SET domain, bifurcated 1

Synonyms

ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21;

Species

Homo sapiens

Ensembl Protein

ENSP00000432348

InnateDB Gene

IDBG-102210 (SETDB1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 165 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	165 [view]
Protein-Protein	164 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0018024	histone-lysine N-methyltransferase activity

Biological Process

GO:0034968

histone lysine methylation

Cellular Component

GO:0005634	nucleus
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001214 SET domain
IPR001739 Methyl-CpG DNA binding
IPR002999 Tudor domain
IPR003606 Pre-SET zinc-binding sub-group
IPR007728 Pre-SET domain
IPR016177 DNA-binding domain

PFAM

PF00856
PF01429
PF00567
PF05033

PRINTS

PIRSF

SMART

SM00317
SM00391
SM00333
SM00468

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite