Version 5.4
Homo sapiens Protein: F13A1
Summary
InnateDB Protein IDBP-59188.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F13A1
Protein Name coagulation factor XIII, A1 polypeptide
Synonyms F13A;
Species Homo sapiens
Ensembl Protein ENSP00000264870
InnateDB Gene IDBG-59186 (F13A1)
Protein Structure
UniProt Annotation
Function Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
Subcellular Localization Cytoplasm. Secreted. Note=Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.
Disease Associations Factor XIII subunit A deficiency (FA13AD) [MIM:613225]: An autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. {ECO:0000269PubMed:1353995}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0002576 platelet degranulation
GO:0007596 blood coagulation
GO:0018149 peptide cross-linking
GO:0030168 platelet activation
Cellular Component
GO:0005576 extracellular region
GO:0031093 platelet alpha granule lumen
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR001102 Transglutaminase, N-terminal
IPR002931 Transglutaminase-like
IPR008958 Transglutaminase, C-terminal
IPR014756 Immunoglobulin E-set
PFAM PF00868
PF01841
PF00927
PRINTS
PIRSF
SMART SM00460
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P00488
PhosphoSite PhosphoSite-P00488
TrEMBL Q9NQP5
UniProt Splice Variant
Entrez Gene 2162
UniGene Hs.713857
RefSeq NP_000120
HUGO HGNC:3531
OMIM 134570
CCDS CCDS4496
HPRD 00604
IMGT
EMBL AB208852 AF418272 AL133326 AL157775 AL391420 BC027963 M14354 M14539 M21987 M21988 M21989 M21990 M21991 M21992 M21993 M21995 M21996 M21997 M21998 M21999 M22000 M22001
GenPept AAA52415 AAA52488 AAA52489 AAH27963 AAL12161 BAD92089 CAC36886 CAI39797 CAO03607

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca