InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRAF1

Summary

InnateDB Protein

IDBP-591936.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRAF1

Protein Name

TNF receptor-associated factor 1

Synonyms

EBI6; MGC:10353;

Species

Homo sapiens

Ensembl Protein

ENSP00000443183

InnateDB Gene

IDBG-83153 (TRAF1)

Protein Structure

UniProt Annotation

Function

Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. {ECO:0000269PubMed:10692572, ECO:0000269PubMed:16323247, ECO:0000269PubMed:18429822, ECO:0000269PubMed:19287455, ECO:0000269PubMed:19698991, ECO:0000269PubMed:20385093}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 124 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	124 [view]
Protein-Protein	122 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031625	ubiquitin protein ligase binding
GO:0031996	thioesterase binding

Biological Process

GO:0006461	protein complex assembly
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:2001236	regulation of extrinsic apoptotic signaling pathway